Cardionerds: A Cardiology Podcast cover image

Cardionerds: A Cardiology Podcast

387. Cardio-Rheumatology: The Role of Inflammation in Cardiovascular Disease with Dr. Antonio Abbate

Aug 18, 2024
Dr. Antonio Abbate, a leading expert in cardio-immunology, sheds light on the crucial link between inflammation and cardiovascular disease. He discusses how chronic low-grade inflammation influences heart health and the role of atherosclerosis as a chronic inflammatory condition. Dr. Abbate emphasizes the significance of inflammatory markers, like C-reactive protein, in assessing cardiovascular risk. The conversation also touches on emerging anti-inflammatory therapies and personalized strategies for managing high-risk patients.
44:29

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Chronic low-grade systemic inflammation significantly contributes to cardiovascular disease progression, especially atherosclerosis, necessitating a deeper understanding of inflammatory mechanisms.
  • Emerging therapies targeting inflammatory pathways, such as monoclonal antibodies, show promise in reducing cardiovascular events in high-risk patients with persistent inflammation.

Deep dives

The Impact of Inflammation on Cardiovascular Disease

Inflammation plays a significant role in the development and progression of cardiovascular disease, particularly atherosclerosis. Research indicates that chronic, low-grade systemic inflammation contributes to adverse cardiovascular events, not only through traditional risk factors but also through inflammatory pathways. Elevated levels of C-reactive protein (CRP), an inflammatory biomarker, have been associated with increased risk for recurrent myocardial infarction, thrombotic events, and heart failure. Understanding the underlying inflammatory mechanisms is essential for identifying patients at residual risk even after standard therapeutic interventions.

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