Challenging Cases in Breast Cancer with CDK 4/6 Inhibitors – Drs. Sara Tolaney & Adam Brufsky

In this episode of the Oncology Brothers podcast, we took a deeper dive into the evolving landscape of CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer. Joined by esteemed oncologists Dr. Sara Tolaney from Dana-Farber Cancer Institute and Dr. Adam Brufsky from UPMC Hillman Cancer Center, the discussion focused on real-world scenarios involving adjuvant and metastatic settings.

Key topics included:
• The recent updates from the MonarchE and NATALEE trials, highlighting the approval of abemaciclib and ribociclib.
• Strategies for selecting the right adjuvant treatment for high-risk patients, including dosing considerations and side effect management.
• Insights into managing common toxicities associated with CDK4/6 inhibitors, such as diarrhea and QTc prolongation.
• The role of CDK4/6 inhibitors in patients with visceral involvement and the implications of using these therapies in the metastatic setting.

Whether you're a healthcare professional or someone interested in the latest advancements in breast cancer treatment, this episode provided valuable insights and expert opinions on navigating complex treatment decisions.

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