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Business Of Biotech
The Allogeneic Future with Poseida's Kristin Yarema, Ph.D.
Aug 5, 2024
Kristin Yarema, Ph.D., the newly-appointed CEO of Poseida Therapeutics, dives into the transformative world of CAR T therapeutics. She envisions a future where allogeneic therapies make life-saving treatments widely accessible. Kristin shares her journey from academia to biotech, emphasizing the benefits of strategic collaborations with companies like Astellas and Roche. The conversation highlights the innovative convertible CAR T approach and the ongoing challenges in scalable production for autoimmune diseases, underscoring the critical role of partnerships in advancing cancer treatment.
01:04:44
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Quick takeaways
- The shift from autologous to allogeneic CAR T-cell therapies aims to enhance treatment accessibility and scalability for patients.
- Dr. Kristin Yarema's diverse career in biopharma equips her with the necessary skills to innovate and lead Poseida Therapeutics effectively.
Deep dives
Autologous vs. Allogeneic CAR T Cell Therapies
The focus of current cell therapy advancements is shifting from autologous CAR T cell therapies to allogeneic approaches, which aim to improve accessibility and scalability of treatments. Poseida Therapeutics is prioritizing this allogeneic method by utilizing healthy donor-derived CAR T cells, allowing for off-the-shelf therapies that can be manufactured at scale. This transition seeks to address the challenges of individualized treatment timelines and costs inherent in autologous therapies. By leveraging this innovative approach, Poseida aims to transform the accessibility paradigm of cell therapies for patients in need.
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