Practical Neurology Podcast Nutritional perils, the immunoglobulin paradox, and a flickering candle - Editors' Highlights June 2025
May 16, 2025
Delve into the complexities of newly identified diseases like IgG4-related disorders and the nuances of genetics with repeat expansion disorders. Explore the nutritional dangers linked to bariatric surgeries and the risks of restrictive vegan diets. Learn about Hoover's sign and its role in functional neurological disorders, as well as the critical review of immunoglobulin therapies in neurology. Finally, engage with the ethical challenges in caring for patients with prolonged disorders of consciousness, highlighting the need for empathy and clear communication.
AI Snips
Chapters
Books
Transcript
Episode notes
IgG4-Related Disease Insights
- IgG4-related disease is a treatable chronic multi-system disorder often misdiagnosed as other conditions like giant cell arteritis.
- Tissue diagnosis is essential, as serum IgG4 testing is neither sensitive nor specific enough for diagnosis.
Repeat Expansion Disorders Unified
- Repeat expansion disorders share genetic and clinical features despite their diversity.
- Whole genome sequencing can't always detect these; long-read sequencing may improve diagnosis and targeted therapy.
Address Nutritional Neuropathy Risks
- Monitor for nutritional neuropathies after bariatric surgery and consider thiamine deficiency.
- Be vigilant with patients adopting restrictive diets or veganism and consider risks of B12 and other vitamin deficiencies.
