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The Drug Discovery World Podcast

DDW Highlights: 18 March 2024

Mar 18, 2024
This podcast highlights the latest in drug discovery, including promising therapies for Alzheimer's and Parkinson's disease, potential treatments for Autism Spectrum Disorder, and advancements in improving ALS complication-free survival and quality of life. The episodes explore the potential of small molecules, new drug candidates, and positive clinical trial outcomes in neurodegenerative diseases.
16:04

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Quick takeaways

  • GAL201 targets toxic alpha-beta oligomers in Alzheimer's disease, showing neuroprotective effects and cognitive improvements.
  • Zalquistanol from Gates Neurosciences demonstrates efficacy in ASD mouse models by enhancing synaptic function and resolving behavioral symptoms.

Deep dives

Innovative Alzheimer's Treatment with GAL201

Gali Medix Therapeutics presented data at the International Conference on Alzheimer's and Parkinson's Disease, ADPD 2024, showcasing GAL201's potential in treating Alzheimer's disease, with neuroprotective effects and cognitive improvements. GAL201, a small molecule, stands out as it targets toxic alpha-beta oligomers and protofibrils, addressing the underlying causes of the disease. Results revealed GAL201's high affinity to misfolded alpha-beta monomers, preventing neurotoxic forms and preserving dendric spines crucial for synaptic plasticity. Behavioral experiments on AD animal models demonstrated improved cognitive performance comparable to healthy mice post GAL201 injection.

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