Ep 37 Serotonin: The Apathy Hormone

Nov 6, 2019

This podcast explores the role of serotonin in depression, motivation, and hormone regulation. It discusses the historical treatment of mental illness and debunks the misconception of low serotonin causing depression. It also explores the use of ketamine as a new treatment option for treatment-resistant depression. The podcast delves into the complex relationship between serotonin and dopamine and the concept of learned helplessness.

Ask episode

Chapters

Transcript

Episode notes

Introduction

00:00 • 2min

The Discovery and Effects of Serotonin, as well as its Relationship with Dopamine

02:24 • 4min

Historical Treatment, Theories, and Manipulation of Depression

06:39 • 5min

Ketamine as a New Treatment for Depression

11:42 • 16min

Misconceptions about Serotonin and Upcoming Interviews

27:36 • 2min

Learned Helplessness and Depression are crucial issues facing humanity today. Serotonin is the key to understanding these issues. Notes: What is Serotonin Health Line: https://www.healthline.com/health/mental-health/serotonin#functions Self-Hacked Serotonin: https://selfhacked.com/blog/serotonin-happy-neurotransmitter/ Depression Article The Guardian: https://www.theguardian.com/society/2018/jan/07/is-everything-you-think-you-know-about-depression-wrong-johann-hari-lost-connections?fbclid=IwAR1-A_G4vdu9R6P-Es7_D7oO59K6C01GnSKOjaij3flVE_41jgKbZIoetx0 Depression is an individualized disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950973/ Selective Publication of Antidepressant Trials: https://www.nejm.org/doi/full/10.1056/NEJMsa065779#t=article Side Effects of SSRIs Outweigh the Benefits: https://www.madinamerica.com/2019/06/researcher-critiques-misleading-claims-antidepressants/ Increase in salivary cortisol with 5-HTP ingestion: https://www.ncbi.nlm.nih.gov/pubmed/12073163 Combining 5-HTP and SSRIs: https://www.ncbi.nlm.nih.gov/pubmed/16378695 -Increases serotonin by %500! Measured through cortisol and prolactin 5-HTP can help nightmares: https://www.ncbi.nlm.nih.gov/pubmed/15146330 Self-Hacked 5_HTP Supplementation: https://selfhacked.com/blog/5-htp-serotonin-depression-risks-benefits/#comments Martin Seligman Learned Helplessness: https://operationcleanrecovery.com/learned-helplessness-seligmans-theory-of-depression-cure/ Ray Peat Serotonin, Disease, Aging, Inflammation: http://raypeat.com/articles/articles/serotonin-disease-aging-inflammation.shtml Ray Peat Serotonin, Depression, and Aggression: The Problem of Brain Energy: http://raypeat.com/articles/articles/serotonin-depression-aggression.shtml Who Discovered Depression: https://www.verywellmind.com/who-discovered-depression-1066770 New Depression Drug Ketamine: https://www.verywellmind.com/who-discovered-depression-1066770 Saffron: https://www.psychcongress.com/article/saffron-effective-some-antidepressants Methylene Blue: https://www.apsf.org/article/methylene-blue-and-the-risk-of-serotonin-toxicity/ Products: Saffron Extract: https://amzn.to/2Oei6NW Music by Jenny Jahlee from Live at KBOO