The Readout Loud 340: Crisis in CRISPR world, RFK Jr.'s promises, and a novel non-opioid pain drug
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Feb 6, 2025 Jason Mast, a reporter for STAT, delves into the troubling downturn in the once-promising CRISPR gene editing field. The discussion highlights the challenges companies face amid market skepticism and compares CRISPR innovations with RNA therapies. The conversation also touches on RFK Jr.'s controversial views as a nominee for HHS secretary, alongside insights into recent pharma earnings that spotlight successes in obesity treatments and the approval of a groundbreaking non-opioid pain drug, revealing the complexities of today’s biotech landscape.
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CRISPR's Downturn
- CRISPR gene editing has transitioned from a lauded technology to a struggling industry.
- Initial excitement and investment have waned due to commercialization challenges and unsolved scientific hurdles.
CRISPR Company Examples
- Intelia, despite positive clinical data, faces investor skepticism due to existing treatments for targeted diseases.
- Prime Medicine, built on a significant gene editing advancement, struggles with complex technology and overly ambitious strategies.
Strategic Advice for Biotechs
- Biotech companies should prioritize staged development and de-risking before seeking large investments.
- Thorough preclinical studies are crucial for demonstrating viability and attracting investors.