In this rebroadcast of the COVID-19 Real-Time Learning Network’s Cultural Awareness series and in honor of Black History Month, Associate Editor and St. Louis Medical Director Dr. Mati Hlatshwayo Davis speaks with Dr. Taison Bell of the University of Virginia and Dr. Stella Safo of Mount Sinai on the impact that historical medical mistrust among Black communities has had on vaccine uptake. The panelists share examples of trusted messengers effectively engaging in conversations about COVID-19 vaccines within their communities.