Neurology Exam Prep Podcast Episode 31 - CNS Tumors
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Apr 27, 2021 Exploring CNS tumors, they discuss incidence rates, challenges in treatment, and mortality. From meningiomas to gliomas, they cover radiological and pathological features, IDH mutations, and targeted therapies. They delve into grade two CNS tumors, MGMT gene impact on treatment outcomes, temozolomide toxicities, and treatment options for glioblastoma. Imaging characteristics of various CNS tumors are also explored.
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Incidence And Impact
- Brain tumors are rare overall but are the most common childhood cancer and carry high mortality due to limited effective treatments.
- Adult incidence is about 40 per 100,000 and childhood incidence about 5 per 100,000 per year.
Most Common Tumor Types
- Meningiomas are the single most common brain tumor and are usually benign, comprising about a third of brain tumors.
- Glioblastomas are the most common malignant brain tumor, making up ~15% of all brain tumors and ~50% of malignant ones.
Recognize Meningioma Imaging
- Identify meningiomas on MRI as dural-based, homogeneously enhancing masses often with a dural tail.
- Look for a CSF clef sign on T2 to confirm they are extra-axial and dural in origin.