OpenAI Podcast Episode 10 - How AI Is Accelerating Scientific Discovery Today and What's Ahead
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Nov 20, 2025 
Kevin Weil, Head of OpenAI for Science, and Alex Lupsasca, an OpenAI research scientist and physicist, explore how GPT-5 accelerates scientific discovery. They discuss its role in literature searches and solving complex physics problems like black hole symmetries. The duo emphasizes GPT-5’s capacity to connect diverse research topics and its application in fusion experiments. They predict significant advancements in science over the next five years, while advising researchers to embrace AI as a collaborator for innovative explorations.
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AI Is Crossing The Scientific Frontier
- GPT-5 is beginning to push past human frontiers in science by proving new things and surfacing novel ideas.
- Small early breakthroughs today could become routine tools for scientists within months.
Solving A Pulsar PDE With GPT-5
- Alex Lupsasca used GPT-5 to simplify a complex infinite-sum solution and find a 1950s identity that applied.
- The model worked through the derivation but introduced a small typo that Alex corrected manually.
AI Unlocks Lost Cross-Disciplinary Literature
- GPT-5 finds conceptual literature links across fields and languages that keyword searches miss.
- This uncovers buried theses and cross-disciplinary work that accelerates research.