ICU Primary PrepCast #Epi 88 - ICU Primary Snippet 31 -Furosemide Vs Acetazolamide
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Apr 11, 2024 Comparing two diuretic medications, Furosemide and Acetazolamide, discussing their pharmacological agents, pharmacokinetics, pharmacodynamics, formulations, contraindications, side effects, and drug interactions. Highlights include distinctions, ototoxicity, anemia, and important considerations.
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Pharmacology Approach
- When answering pharmacology questions, organize your response by pharmacokinetics and pharmacodynamics.
- This ensures comprehensive coverage of crucial aspects, from absorption and distribution to effects and interactions.
Diuretic Differences
- Furosemide and acetazolamide, while both diuretics, differ in bioavailability and onset of action.
- Furosemide's bioavailability is lower, especially in renal failure patients, and its IV administration should be slow to prevent ototoxicity.
Mechanism of Action
- Furosemide acts on the loop of Henle, blocking a specific transporter and increasing water excretion.
- Acetazolamide inhibits carbonic anhydrase in the proximal tubule, affecting sodium and bicarbonate reabsorption.