FF 87 Can Fish Oil Knock the Crap out of Dialysis Associated CV Disease?

The Filtrate

Joel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)

Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn

Pedro Teixeira @nephcrit.bsky.social

Special Guests

Charmaine E Lok, MD Professor of Medicine at the Faculty of Medicine, University of Toronto

Editing and Show Notes by

Joel Topf

The Kidney Connection written and performed by Tim Yau

Show Notes

Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis NEJM | NephJC

What works in hemodialysis?

Iron: PIVOTAL Trial (NEJM)

Hemodiafiltration: CONVINCE (NEJM)

That’s the whole list

Earlier work on vascular access, The FISH Trial: Effect of fish oil supplementation on graft patency and cardiovascular events among patients with new synthetic arteriovenous hemodialysis grafts: a randomized controlled trial JAMA

Eskimo myth: "Fishing" for the origins of the "Eskimos and heart disease" story: facts or wishful thinking? (PubMed)

Dialysis patients have low levels of fish oil in their body (PubMedCentral)

Positive trial in non-dialysis patients: REDUCE-IT

Negative trial of fish oil in non-dialysis patients: STRENGTH

ACC does not recommend FISH Oil for primary or secondary prevention of CV events (ACC)

Poisson distribution (Wikipedia)

Ocean Nutrition Canada (Wikipedia)

Ocean Nutrition was bought by DSM (Press Release)

DSM merged with Firmenich (Press Release)

Vanguard feasibility trials (PubMed)

Freezing fish oil caps will eliminate the fishy aftertaste (Pharmacists Letter)

The study also received a philanthropic donation from Mr. Alexander Epstein (UHN Research)

Selection Bias, Interventions and Outcomes for Survivors of Cardiac Arrest (PubMedCentral)

Effectiveness of fish oil in controlling inflammation in adult patients undergoing hemodialysis: A systematic review and meta-analysis (PubMed)

Tubular Secretions

Swapnil Hiremath: Michael Clayton (IMDB)

Pedro: Fifa World Cup Soccer coming to North America with Portugal! (FIFA)

Charmaine: New Puppy, Rose. It’s a Barbet (Wikipedia)

Joel Topf: The Dark Forrest by Liu Cixin (Wikipedia)