CM#9: Peptides Part 1 - Beyond More is Better: Precision Approaches to Peptides and Cellular Health

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Aug 5, 2025

Chris Duffin hosts Anthony Castor, an expert in cellular medicine and peptides, as they dive into the art of optimizing health and recovery through targeted peptide protocols. They emphasize that precision beats overload; understanding your body's specific needs is crucial. Anthony highlights the importance of mapping cellular pathways to avoid counterproductive combinations. The duo discusses how effective supplementation can enhance performance, stressing the need for a streamlined approach to training and wellness that yields maximum benefits.

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INSIGHT

Target Training Bottlenecks with Peptides

Effective peptide protocols start with identifying training bottlenecks and supporting specific cellular pathways.
Choosing peptides that align with those pathways avoids overlap and enhances the training stimulus.

ADVICE

Avoid Counterproductive Peptide Combos

Avoid combining peptides that counteract each other as it can create negative effects.
Understand mechanisms to ensure peptides complement rather than cancel one another.

INSIGHT

Balance Mitochondrial Complex Support

Overloading uneven mitochondrial complexes with peptides can cause oxidative stress.
Balanced support of mitochondrial complexes is essential to avoid cellular damage.

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Chris Duffin is joined by Anthony Castor for an in-depth exploration of peptides and their role in optimizing health, training, and recovery.

Together, they break down the complexities of building peptide protocols—discussing how to identify bottlenecks in your own training or wellness, the art and science of combining interventions effectively (without overcomplicating or wasting resources), and why understanding cellular pathways and mechanisms of action matters.

Whether you’re curious about cellular medicine, looking to fine-tune your supplement stack, or just want sharper tools in your resilience toolbox, this episode offers practical, actionable wisdom to help you get the most out of your health and performance strategies—without unnecessary complexity. Let’s get started!

Here are my top three takeaways from the episode:

Precision Beats Overload: When it comes to peptides (and training), more isn’t always better. Identify your “bottlenecks” and use the least amount of intervention necessary. Streamline your approach and only deploy peptides with mechanisms that authentically support your goals.
Understand the Mechanisms: Before layering in another supplement or peptide, take the time to map out which cellular pathways you want to target—and avoid overlap or counterproductive combinations. Knowing howsomething works is crucial to making smart choices (the “why” matters, not just the “what”).
Continuous Assessment is Key: Monitor progress with clear performance indicators—whether that's lab work, improved cognition, or how you feel. Be ready to adjust your protocol, rotate interventions, and remove what you no longer need.

This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by

@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin

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00:00 Optimizing Training with Peptides

03:45 "Optimizing Peptide Pathways"

07:14 Insulin Sensitivity and Oxidative Stress

12:17 Streamlined Supplement Strategy

15:40 Optimal Training: Quality Over Quantity

17:16 Understanding Key Performance Indicators

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