Lex Fridman Podcast

#153 – Dmitry Korkin: Evolution of Proteins, Viruses, Life, and AI

Jan 11, 2021

02:18:10

Creator website

Highlights

AI Chapters

Episode notes

Using Machine Learning to Predict Mutations

01:39

The Computer and the Brain by Jonathan Neumann

02:12

Bioinformatics Olympic Games - AlphaFault 2

02:03

Introduction

3min

Why I Love Magic Spoon Low Carb Cereal

2min

Sleep.com Slash Lex Review

1min

Protein Domains Are the Building Blocks of Life

3min

Protein Domains - The Basic Building Block of Complex Function

5min

Is There Something Interesting About the Spike Protein?

4min

Is the Spike Protein Really a Trimer of the Virus?

3min

Is the Envelope of a Virus Really a Complex?

2min

Virus Security Perspective - Is This the Best Attack Vector?

2min

10.

Mutations of the Virus

2min

11.

Are You Worried About the Arms Race?

2min

12.

Is There a Capacity of a Virus to Become More Efficient?

2min

13.

The Evolution of Proteins - Part Two

4min

14.

The Concept of Alternate Splicing

6min

15.

Can We Replicate These Ideas From Cells?

2min

16.

Is Machine Learning a Natural Evolution?

2min

17.

Evolution Algorithm

3min

18.

The Drake Equation That Estimates How Many Aliens Are There?

4min

19.

The Rare Earth Hypothesis

3min

20.

Is There a Way to Find Life?

2min

21.

Alpha Fold

6min

22.

Andre Salle, Professor Emeritus at Rockefeller University

2min

23.

How to Study Extraterrestrial Molecules

2min

24.

Why Expert Systems Didn't Become Successful?

3min

25.

Bioinformatics Olympic Games - AlphaFault 2

2min

26.

Protein Folding - What Is It?

2min

27.

Protein Structure Prediction Algorithm

2min

28.

Is It Possible to Reconstruct the 3D Structure of a Protein?

3min

29.

Machine Learning - Alpha Fall Two

3min

30.

The Evolution of Protein Folding, Right?

2min

31.

The Problem With Multi-Domain Protein Faults

3min

32.

The Greatest Breakthroughs in Artificial Intelligence History

4min

33.

Is Deep Rembrandt a Fundamental Aspect of Intelligence?

2min

34.

Is There a Moment Where AI Creates Music?

5min

35.

The Multi-Domain Protein Problem?

3min

36.

Is It a Level of Complexity?

2min

37.

Do You Think Alpha Fold 2 Will Lead to a Nobel Prize?

3min

38.

Do You Think Machine Learning Could Be Used to Engineer Viruses?

3min

39.

Using Machine Learning to Predict Mutations

2min

40.

Is There a Regulation of the Research on Influenza?

2min

41.

Machine Learning and the Drake Equation

2min

42.

Virus Engineering as a Weapon

2min

43.

What Have You Learned From SARS?

2min

44.

Is There a Future Pandemic of Viruses?

3min

45.

The Solzhenitsyn's Cancer

4min

46.

The Computer and the Brain by Jonathan Neumann

2min

47.

Lab Girl by Hope Jaren by Ed Witten

2min

48.

New Year's Resolutions

3min

49.

Is There a Russian Poem You Can Read?

3min

50.

A Kiss in Winter Is an Interesting Lips in Winter

2min

Dmitry Korkin is a professor of bioinformatics and computational biology at WPI. Please support this podcast by checking out our sponsors:
– Brave: https://brave.com/lex
– NetSuite: http://netsuite.com/lex to get free product tour
– Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings

EPISODE LINKS:
Dmitry’s Website: http://korkinlab.org/
Dmitry’s Twitter: https://twitter.com/dmkorkin

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
Apple Podcasts: https://apple.co/2lwqZIr
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
– Check out the sponsors above, it’s the best way to support this podcast
– Support on Patreon: https://www.patreon.com/lexfridman
– Twitter: https://twitter.com/lexfridman
– Instagram: https://www.instagram.com/lexfridman
– LinkedIn: https://www.linkedin.com/in/lexfridman
– Facebook: https://www.facebook.com/LexFridmanPage
– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:21) – Proteins and the building blocks of life
(14:23) – Spike protein
(21:11) – Coronavirus biological structure explained
(26:09) – Virus mutations
(32:39) – Evolution of proteins
(42:25) – Self-replicating computer programs
(50:02) – Origin of life
(57:34) – Extraterrestrial life in our solar system
(59:31) – Joshua Lederberg
(1:05:30) – Dendral
(1:08:24) – Why did expert systems fail?
(1:10:35) – AlphaFold 2
(1:32:13) – Will AI revolutionize art and music?
(1:39:12) – Multi-protein folding
(1:43:39) – Will AlphaFold 2 result in a Nobel Prize?
(1:46:10) – Will AI be used to engineer deadly viruses?
(2:01:17) – Book recommendations
(2:11:00) – Family
(2:13:38) – A poem in Russian