866: Bringing Back Extinct Animals like the Woolly Mammoth and Dodo Bird
Feb 28, 2025
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The podcast dives into the fascinating realm of bringing extinct animals back to life, focusing on the woolly mammoth and dodo bird. It highlights the groundbreaking work of Colossal Biosciences and their use of genomic technologies, like CRISPR and artificial wombs. Discussions also touch on the implications for conservation, biodiversity credits, and the ethical aspects of playing god with nature. Can science really resurrect history? The conversation reveals both excitement and caution surrounding these ambitious biotech projects.
Colossal Biosciences is pioneering the resurrection of extinct species like the woolly mammoth and dodo bird through advanced genome mapping and CRISPR technology.
Their innovative approach not only focuses on de-extinction but also creates commercial value and aids conservation efforts for endangered species.
Deep dives
The Intersection of De-Extinction and Technological Innovation
A key focus of the episode is the groundbreaking work by a company called Colossal Biosciences, which aims to bring extinct animals back to life, such as the woolly mammoth and dodo bird. Through advanced biotechnology, they map the genomes of these extinct species and compare them to closely related living species, utilizing CRISPR gene editing to modify cells. These modified cells are then implanted into surrogate mothers, creating an avenue not just for de-extinction but also for innovations like artificial womb technology. The ambition behind this endeavor highlights the potential for significant commercial applications across various industries, showcasing how big dreams can lead to meaningful advancements in technology and conservation efforts.
Business Models and Broader Implications of De-Extinction
Colossal's approach is not limited to bringing back extinct species; they are also leveraging their expertise in multiple ways to create commercial value. They have established successful ventures like Breaking, which helps in plastic waste reduction, and FormBio, a platform for developing gene therapies. Additionally, they collaborate with governments on conservation projects for endangered species, such as the northern white rhinoceros, while positioning themselves to enter the biodiversity credits market. This illustrates how pursuing a grand vision can yield secondary innovations that address urgent global challenges, thus emphasizing the value of ambition combined with advanced technology.
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Resurrecting the Past: Biotechnology's Quest to Bring Back Extinct Animals
Jon Krohn addresses a question for the ages: How close are we, really, to Jurassic Park? Dallas-based biotech company Colossal Biosciences is developing technology that aims to return previously extinct animals like the dodo and woolly mammoth to earth and, crucially, pull many others like the white rhino back from the brink of extinction.