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Critical Care Scenarios

Episode 84: Acute liver failure with Sergio Navarrete

Jan 22, 2025
Join Dr. Sergio Navarrete, an expert in transplant anesthesia, as he navigates the complex world of acute liver failure management. He dives into the critical assessment of liver function, highlighting the balance of supportive care and the importance of hemodynamic optimization. Discover the evolving role of N-acetylcysteine and the challenges of cerebral edema linked to ammonia levels. Dr. Navarrete emphasizes the intricacies of coagulopathy and the vital considerations for timely liver transplantation, showcasing his depth of knowledge in this high-stakes field.
56:39

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Quick takeaways

  • Effective supportive care and careful fluid management are essential for stabilizing patients with acute liver failure and preventing complications.
  • Timely referral for transplant evaluation is crucial, especially for patients with severe liver dysfunction, to improve survival rates and outcomes.

Deep dives

Understanding Acute Liver Failure

Acute liver failure can present as a significant challenge in critical care settings, especially when accompanied by septic shock and other multi-organ dysfunctions. In this case, a 41-year-old male with a history of cirrhosis developed severe liver enzyme elevations and bilirubin levels due to shock liver, highlighting the importance of monitoring liver function in critically ill patients. Elevated transaminases, particularly in the thousands, are concerning indicators suggesting potential acute liver failure or shock liver. Clinicians must assess the underlying causes and consider whether the symptoms indicate simple shock liver or more severe hepatic involvement that demands urgent treatment.

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