The Orthobullets Podcast

Foundations⎪Pathology⎪Paget's Disease

Jun 15, 2025
Explore the intricate details of Paget's disease, including its unique bone remodeling processes. The discussion dives into the disease's epidemiology and pathophysiology. Discover diagnostic criteria and effective treatment strategies for both asymptomatic and symptomatic patients. Perfect for budding MSK providers seeking foundational knowledge!
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INSIGHT

Paget's Disease Pathophysiology

  • Paget's disease involves abnormal bone remodeling with increased osteoclastic resorption and disorganized bone formation.
  • It mostly affects patients over 40 and is often incidentally found on radiographs without symptoms.
INSIGHT

Osteoclastic Role in Symptoms

  • Primary cellular issue in Paget's disease is increased osteoclastic bone resorption.
  • Manifestations include bone pain, deformities like long bone bowing, fractures, and secondary sarcoma risk.
INSIGHT

Imaging Features of Paget's

  • Radiographs show coarse trabeculae with both increased and decreased bone density depending on disease phase.
  • Look for remodeled cortices, bowing, fractures, and arthritis; sarcoma shows cortical destruction and soft tissue mass.
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