

283: A CRISPR milestone, algorithms amok, & biotech mixology
11 snips Nov 16, 2023
Investigative reporter Casey Ross reveals how UnitedHealth Group used an algorithm to deny patient care for profit. Biotech veteran Michael Gilman talks about being a startup CEO in the economic downturn and shares cocktail recipes. They also discuss the approval of a groundbreaking CRISPR-based medicine.
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CRISPR-Based Medicine Approved
- Casgevy is the first CRISPR-based medicine approved, marking a major step for sickle cell treatment.
- The UK approved it for both sickle cell disease and beta thalassemia, another blood disorder.
Casgevy's UK Launch and Pricing
- Casgevy's UK rollout involves negotiations with NICE for reimbursement and patient access.
- Pricing isn't disclosed yet, and the UK patient population is relatively small.
UnitedHealth's Algorithm and Case Management
- UnitedHealth's algorithm uses patient data to predict rehab stay length, influencing payment decisions.
- Case managers face pressure to adhere to the algorithm's predictions with little discretion.