Child Neurology Society's Brainstorm CNS Brainstorm Episode 29 "AIDP" with guest Dr. Ryan Cappa
Mar 23, 2025
In this discussion, Dr. Ryan Cappa, an Assistant Professor of Neurology specializing in Pediatric Neuromuscular Medicine at the University of Virginia, dives into Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP). He explains its link to Guillain-Barré syndrome and emphasizes its clinical features, particularly in children. The conversation addresses diagnostic challenges, the importance of thorough examinations, and the role of IVIG therapy. Dr. Cappa also discusses variant presentations like AMAN and Miller-Fisher syndrome, highlighting the critical need for careful monitoring in pediatric cases.
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AIDP and GBS Relationship
- AIDP is the most common form causing acute flaccid paralysis in children, affecting myelin and multiple nerve roots.
- Guillain-Barré syndrome (GBS) broadly encompasses AIDP and related inflammatory neuropathies.
AIDP Epidemiology and Age Range
- AIDP incidence approximates one per 100,000 with a peak in children around 2 years old.
- Neonatal cases exist so AIDP should be considered even in floppy infants.
Typical Clinical Presentation of AIDP
- AIDP typically presents as symmetric ascending weakness with reduced reflexes and progression over days to weeks.
- Cranial nerve involvement and pain are common; a preceding infection often triggers symptoms but isn't required.