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The Royal House of Habsburg, one of the most powerful dynasties of Medieval and Renaissance Europe, reigned over much of Europe for centuries. But genetic inheritance and the perils of inbreeding may explain their demise.

Like many royal families their expansion and hold on power came about in part through inter-family marriages. But over time, generation after generation of inbreeding, helped contribute to some of the physical ailments that often plagued the family as well as the distinctive look with their big lower lips, long noses and the distinctive “Habsburg jaw.”

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