Bone marrow in the skull plays a surprisingly important role in ageing
Nov 13, 2024
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Bong Ng Kho, an author focused on skull bone marrow's role in aging, discusses how this area becomes vital for blood-cell production as we age, offering potential insights into neuroinflammation. Guy Leckenby, a researcher studying lead-205 isotopes, illuminates new methods for dating the Solar System, showcasing how stellar conditions influence their decay. Together, they highlight the surprising resilience of skull marrow and innovative cosmic dating techniques, leaving listeners intrigued by aging and the cosmos.
Skull bone marrow expands with age, helping maintain blood-cell production and potentially countering neuroinflammation, unlike other bone marrows which decline.
User behavior significantly influences the spread of misinformation, suggesting that users actively seeking unreliable information are a key factor in the issue.
Deep dives
The Role of Skull Bone Marrow in Aging
Research shows that skull bone marrow may play a significant role in maintaining health as people age. Unlike other bone marrows, which experience deterioration in function due to various factors such as loss of blood vessels and inflammation, skull bone marrow appears to expand and retain its hematopoietic function throughout the lifespan. This finding suggests that the skull's bone marrow may compensate for declining functions in other bone compartments as individuals age. The unique structure of skull bone marrow, with its connection to the brain's protective membranes, further indicates its potential role in countering neuroinflammation that increases with age.
Differences in Bone Marrow Compartments
The study highlights significant differences between the skull's bone marrow and that found in other bones, challenging previously held assumptions that all bone marrow compartments behave similarly. Researchers noted that the hematopoietic stem cells in the skull marrow remain resistant to the inflammation typically seen in aged bone compartments, allowing for sustained production of blood cells. This newfound understanding could redefine perspectives on bone marrow heterogeneity and emphasize organ functional specialization. Furthermore, the findings may lead to novel insights into how certain organs can resist age-related decline, suggesting the potential for targeted therapies to promote healthy aging.
Lead Isotope Research and Solar System Dating
A breakthrough in lead isotope research offers a new method for dating the solar system's formation. Scientists are examining lead-205, which has a half-life of 17 million years, as a reliable clock for dating ancient events. The study explores how this isotope is produced in stars and its decay process, which has been challenging to quantify due to various factors. By recreating stellar conditions in the lab, researchers are closer to determining the amount of lead-205 available in the interstellar medium during the early solar system, which can help establish a timeline for planetary formation.
Influence of User Behavior on Misinformation
Recent findings indicate that user behavior plays a more significant role in the spread of misinformation compared to search engine algorithms. A study analyzing users' interactions with Bing search results found that unreliable web pages are accessed primarily because users actively choose to search for them, rather than being predominantly driven by algorithmic exposure. The research revealed that unreliable information appeared in a small percentage of searches, suggesting that the context and intent behind searches greatly influence the consumption of such content. These insights highlight the importance of user agency in addressing the misinformation problem, underscoring the need for critical evaluation of information sources.
During ageing, bone marrow in the skull becomes an increasingly important site of blood-cell production. This is in stark contrast to most bones where the ability of marrow to make blood and immune cells declines. Studies in mice and humans showed that ageing results in skull bone-marrow expanding, and in mice this marrow was more resistant to inflammation and other hallmarks of ageing. The team behind the work hope by understanding this process better it may be possible to help organs become more resistant to ageing.
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11:38 How to make lead a useful material to date the Solar System
Researchers have overcome a major hurdle preventing the radioactive isotope lead-205 from being used as a ‘clock’ to date the age of the Solar System. 205Pb is made in some stars and thanks to its half life of around 17 million years has been proposed as a potential way to date ancient astronomical processes. However, exactly how much 205Pb can escape a star were unclear, limiting its dating potential. Now, researchers have mimicked the conditions seen in stars to pin down how much 205Pb can escape into space, paving the way for its use as a clock.