StrictlyVC Download Vinod Khosla on softening the blow from AGI, and other future bets
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Nov 7, 2025 
Vinod Khosla, the founding CEO of Sun Microsystems and venture capitalist at Khosla Ventures, dives into the future of entrepreneurship in a world dominated by AI. He asserts that every profession is a startup opportunity and discusses his vision for building AI workers to replace high-value jobs. Khosla forecasts a dramatic rise in Fortuna 500 company failures and advocates for a national wealth-sharing strategy. Additionally, he reveals his early investment in OpenAI, critiques U.S. immigration policies, and describes innovative energy solutions like fusion and geothermal.
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Build Full AI Workers Not Just Tools
- Build an AI worker that performs a full profession rather than a tool that helps a human.
- Target replacing high-value human roles (e.g., neurologist, oncologist) to capture more value.
Design Around What Models Won't Cover
- Think carefully about what general models will cover and what you must build yourself.
- Build data moats and modes that deliver increasing returns from early scale.
Fortune 500 Faces Accelerated Turnover
- The Fortune 500 will see a much higher churn as incumbents fail to adapt to AI-driven change.
- This creates massive opportunity for founders to capture displaced business.