Cardiopulmonary Interactions with Dr. Bradley Fuhrman -- Part 2
Sep 11, 2023
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Dr. Bradley Fuhrman, an expert in pediatric critical care, discusses cardiopulmonary interactions. Topics include the impact of intubation and positive pressure ventilation on cardiovascular physiology, the relationship between right and left ventricular performance, and the muscle connection in pericardial tamponade. The hosts emphasize the importance of seeking medical advice and express excitement about interviewing Fuhrman.
Positive pressure ventilation affects all four major heart-lung interactions, with potential benefits in improving cardiac output and acid-base balance while also increasing venous return and reducing pulmonary vascular resistance.
In patients with pulmonary hypertension, maintaining normal oxygen and carbon dioxide levels, balancing lung volume near functional residual capacity (FRC), and optimizing alveolar P02 are crucial for minimizing pulmonary vascular resistance and improving patient outcomes.
Deep dives
Positive pressure ventilation and its effects on cardiopulmonary interactions
When moving from negative to positive pressure ventilation, the patient's oxygen demand and demand for cardiac output decrease, resulting in an overall improvement. Positive pressure ventilation affects all four major heart-lung interactions. It increases juxtapacardiac pressure on the right side, which may impede venous return. However, in patients with stiff lungs, the increase in juxtapacardiac pressure may not be significant. On the other hand, patients with normal lung function can experience a substantial increase in juxtapacardiac pressure and reduced venous return. Positive pressure ventilation also raises alveolar pressure, which impedes blood flow through the lungs and increases pulmonary vascular resistance. However, it can be beneficial in restoring acid-base balance and reducing pulmonary vascular resistance. Lastly, positive pressure ventilation affects preload by shifting the ventricular septum to the left and reducing left ventricular volume. However, it may also facilitate emptying of the heart insistally, reducing myocardial workload. Managing high-risk patients going into intubation and understanding these cardiovascular changes is crucial.
Optimizing ventilator settings in a patient with pulmonary hypertension
In patients with pulmonary hypertension, it is crucial to avoid factors that increase pulmonary vascular resistance, such as hypercarbia and acidosis. While lung-protective strategies are commonly used, these may not be advantageous in patients with pulmonary vascular disease. Maintaining normal oxygen and carbon dioxide levels is important for minimizing pulmonary vascular resistance. Ventilating the patient near functional residual capacity (FRC) helps in balancing lung volume. Monitoring the patient's x-ray to ensure they are not over-inflated or under-inflated is essential since deviations from FRC can affect vascular resistance. Considerations also include optimizing oxygenation and ensuring good alveolar P02, as it contributes significantly to pulmonary vascular resistance.
Positive pressure ventilation in patients with LV systolic dysfunction and RV diastolic dysfunction
In patients with left ventricular (LV) systolic dysfunction, positive pressure ventilation can provide positive effects by reducing the myocardial workload and oxygen demand while boosting the intercavitary pressure during ejection. This reduces the force required for LV ejection, thereby benefitting the ischemic myocardium. On the other hand, patients with right ventricular (RV) diastolic dysfunction may experience limited left ventricular filling due to a shift of the ventricular septum towards the LV. The presence of pulmonary insufficiency, usually associated with pulmonary valve or infundibular issues, can further impede LV inflow. Nevertheless, positive pressure ventilation can still be beneficial in supporting LV function and reducing the risk of cardiac arrest.
Bradley Fuhrman, MD completed his training in pediatrics followed by fellowships in cardiology and neonatology at the University of Minnesota where he went on to found the first PICU and serve as the Chief of critical care at that institution. He has also served as the associate director of the PICU at Children’s Hospital of Pittsburgh, Division Chief of Critical Care at Children’s Hospital Buffalo and Physician-in-Chief at El Paso Children’s Hospital. His career in pediatric critical care exceeds 40 years. He has many peer-reviewed publications with a research career that is focused in cardiac and respiratory physiology. He is also the co-author of Fuhrman and Zimmerman’s Pediatric Critical Care.
Learning Objectives:
By the end of listening to this 2-part series, learners should be able to discuss clinically relevant cardiopulmonary interactions and a fundamental clinical approach to optimizing cardiopulmonary mechanics in patients with:
Spontaneous (negative pressure) respirations with severe work of breathing
Septic shock
Mechanical (positive pressure) ventilation
Pulmonary hypertension with right ventricular systolic dysfunction
Left ventricular systolic dysfunction
Right ventricular diastolic dysfunction
Single ventricle Fontan circulation
References:
Bronicki RA, Penny DJ, Anas NG, Fuhrman B. Cardiopulmonary Interactions. Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S182-93. doi: 10.1097/PCC.0000000000000829. PMID: 27490598.
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Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.comfor detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.
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