Continuum Audio Muscle Channelopathies and Rhabdomyolysis with Dr. Hani Kushlaf
Nov 12, 2025
Dr. Hani Kushlaf, a neurology and pathology professor at the University of Cincinnati, dives into the complex world of muscle channelopathies and rhabdomyolysis. He shares his journey from epilepsy to neuromuscular medicine, revealing the latest updates on genetic causes and treatment hopes. Listeners learn about changing definitions of rhabdomyolysis, the significance of initial workups, and the use of the RABDO acronym for genetic testing. The discussion also covers the clinical impact of genetic disorders and practical examination tips for recognizing muscle dysfunction.
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Scope And Promise Of Muscle Channelopathies
- Muscle channelopathies include myotonic disorders, periodic paralysis, and genetic rhabdomyolysis causes that need focused review.
- Progress is limited but new findings and genetic approaches promise future advances.
Progression Independent Of Attack Frequency
- Some periodic paralysis patients develop progressive fixed weakness unrelated to attack frequency.
- This reveals these disorders can progress even when episodic events decrease.
Update CK Cutoffs For Rhabdomyolysis
- Use higher CK thresholds to define rhabdomyolysis: >10,000 after exertion and >5,000 without exercise.
- Avoid labeling athletic high CK as rhabdomyolysis to prevent misdiagnosis.