Stuff You Should Know

How Antidepressants Work

214 snips
Mar 13, 2025
Discover how antidepressants like SSRIs and tricyclics tackle depression, despite the mystery behind their mechanisms. Explore the history and evolution of these medications and their surprising origins. Learn about innovative treatments like psychedelics and nutraceuticals, alongside the necessary dietary precautions when using MAOIs. Hear engaging discussions on personal experiences with depression, alongside the complexities of treatment options and new mental health challenges emerging today.
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ADVICE

Hope for Depression Treatment

  • Depression is highly treatable, and there's hope for recovery.
  • If you're struggling with depression, don't hesitate to seek help.
INSIGHT

Depression and the Biological Model

  • Depression is often treated using the biological model, which focuses on neurotransmitter imbalances.
  • However, studies show that people with MDD don't always have lower serotonin levels, challenging this model.
INSIGHT

Antidepressant Effectiveness

  • Antidepressants work better than placebos, suggesting a real effect.
  • The exact mechanism of how they alleviate depression remains unclear.
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