#01 Reason, the Founder & CEO of Repair Biotechnologies | How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis

Oct 12, 2021

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INSIGHT

Aging as Damage

Aging is like rust: a simple process of damage accumulation.
In complex organisms like humans, this damage manifests in complex ways.

INSIGHT

Evolution's Focus

Evolution prioritizes early-life success, leading to systems optimized for short-term use.
Our immune system, for example, functions well initially but declines with age.

ADVICE

Focus on Repair

Focus on repairing age-related damage instead of solely explaining it.
Study the differences between organisms with and without repaired damage to understand aging's effects.

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Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem.

Reason is perhaps most well known for his popular blog Fight Aging! where he distills the latest research in aging science. For anyone looking to stay informed on aging & longevity research, I highly recommend you checking it out - it’s one of the best resources out there.

In today’s conversation, we discuss how to think of aging simply, the differences between slowing and reversing aging, NAD+ boosters and their effectiveness, reversing aging using senolytics, how his company is working on a gene therapy to reverse artherosclerosis and cardiovascular disease, problems with Alzheimer's research, working towards aging rejuvenation therapies, how one can get involved in the aging space, and much more.

Note: We discuss a fair bit on cellular senescence and senolytic therapies. For those unfamiliar with the concept, cellular senescence is a process in which cells lose their ability to divide but refuse to die. When these senescent cells don’t get cleared away, they release harmful substances and damage the cells around them too.

It is well known that senescent cells accumulate with age, contributing to inflammation and aging itself. Senolytics is a class of drugs that can selectively clear away these senescent cells and they have shown promise in delaying and preventing age-related diseases.

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FOLLOW REASON AND REPAIR BIOTECHNOLOGIES:

Fight Aging! Blog: https://www.fightaging.org/

Company Website: https://www.repairbiotechnologies.com/