Prof. Mervyn Singer on Sepsis, SIRS, Syndromes, and the State of the Art.

Mervyn Singer is a ludicrously busy and accomplished intensivist and professor at University College London. He is a prolific and provocative publisher, researcher and innovator, and our go to guy for all things Sepsis, Syndromes and (basic) Science. This is a fun and informative chat: many thanks Merv!   Further Reading: 1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287 2. Shankar-Hari M, Phillips GS, Levy ML, et al. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):775-787. doi:10.1001/jama.2016.0289 3. Póvoa P, Coelho L, Dal-Pizzol F, et al. How to use biomarkers of infection or sepsis at the bedside: guide to clinicians. Intensive Care Med. 2023;49(2):142-153. doi:10.1007/s00134-022-06956-y 4. Singer M. Personalizing Sepsis Care. Crit Care Clin. 2018;34(1):153-160. doi:10.1016/j.ccc.2017.08.011 5. Singer M. Sepsis: personalization v protocolization?. Crit Care. 2019;23(Suppl 1):127. Published 2019 Jun 14. doi:10.1186/s13054-019-2398-5 6. Morelli A, Ertmer C, Westphal M, et al. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013;310(16):1683-1691. doi:10.1001/jama.2013.278477 7. Singer M, Shipley R, Baker T, Cowell A, Brealey D, Lomas D. The UCL Ventura CPAP device for COVID-19. Lancet Respir Med. 2020;8(11):1076-1078. doi:10.1016/S2213-2600(20)30422-7