There are many reasons why osteoarthritis (OA) might develop in the first place, the progression of the disease can vary dramatically between different individuals and their response to different treatments can similarly be quite distinct. With the greater understanding OA pathophysiology, OA can often be described as a spectrum of disease composed of different phenotypes. Some people have even described this as a mixed bag of disorders or falling under the osteoarthritis umbrella. By characterising OA into phenotypes, it helps to improve our knowledge of the disease, and ultimately enables targeted treatment based on the phenotype that a patient presents with.

On this episode of Joint Action, we will be speaking to Dr Francis Berenbaum to learn more about osteoarthritis phenotypes, how they are identified and how this affects the management of OA.

Dr. Berenbaum is Professor of rheumatology at Sorbonne Université and is the Director of the Department of Rheumatology at AP-HP Saint-Antoine Hospital in Paris, France. He is the national representative of bone and joint diseases at AVIESAN, the French Alliance for the Life Science and Health.

He is a member of the EULAR Public Affairs Group and is a former member of the EULAR Scientific Program committee in 2018-2020. He is a former president of OARSI (Osteoarthritis Research Society International) in 2008-2010 and of the French Society of Rheumatology in 2014-2016. He is Associate Editor of the Annals of the Rheumatic Diseases. Dr Berenbaum leads an experimental team at INSERM institute. His basic research interests include the understanding of relationships between metabolic diseases and osteoarthritis. His clinical research focuses on new targeted therapies for treating symptoms and structural changes in osteoarthritis. He is involved in several clinical trials either from public or private partners. He has published more than 300 peer-reviewed publications.

RESOURCES

Journal articles

• Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns
• The Phenotypic Approach to Osteoarthritis: A Look at Metabolic Syndrome-Associated Osteoarthritis
• Deep phenotyping of osteoarthritis: a step forward

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