Mark and Seth get further into the specifics of Marcus's metaphysics and how this is supposed to relate to behavior. Can his directives really come solely "from reason" as he claims? How does this interact with the behaviors that we pursue "by nature," i.e., without conscious deliberation required?
Seth is concerned with how individualistic the philosophy is. Mark is concerned that if you discard the metaphysics (as modern skeptics largely do), why should you expect the rest of the philosophy to be coherent?
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The Partially Examined Life Philosophy Podcast