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Multiple Definitions, Same Clinical Need
- Long COVID has many names (Long COVID, post-COVID conditions, PASC) with slightly different timing definitions.
- Focus on validating symptoms and assessing whether an alternative diagnosis explains them.
Multifactorial Pathogenesis
- Proposed mechanisms include post-inflammatory changes, immune dysregulation, autoantibodies, and possible viral persistence.
- Ongoing research is needed; several mechanisms may act together in different patients.
Not New, But Much Bigger
- Post-viral syndromes are not unique to SARS-CoV-2; similar sequelae appeared after Ebola, SARS-1, and other infections.
- The scale of COVID-19 magnified recognition and demand for care.