TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful

TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• VITT-like disorder after adenovirus infection (NEJM)
• The clot thickens (TWiV 842)
• Lessons from VITT (Nat Rev Immunol)
• Pan-sarbecovirus neutralizing mAb (Sci Adv)
• Letters read on TWiV 1037
• Timestamps by Jolene. Thanks!

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