Diagnosing the Invisible: How Senseye Is Reinventing Mental Health With AI

In this episode, recorded live at Austin Tech Week 2025, Nick Spiller sits down with David Zakariaie, founder and CEO of Senseye, the Austin-based deep-tech company turning eye-tracking and computer vision into the world’s first objective diagnostic for mental health. Zakariaie explains how Senseye’s 10-minute smartphone-based test measures ocular micro-movements to detect PTSD, anxiety, and depression, conditions currently “diagnosed” using little more than questionnaires and gut instinct.

David walks through the scientific foundation: decades of fMRI research showing clear neurological signatures across mental health disorders, paired with Senseye’s breakthrough, running high-precision eye-tracking with nothing more than a phone camera. The result is a scalable, FDA-bound diagnostic platform aimed at modernizing the world’s most outdated healthcare category.

Nick and David dive into Senseye’s origins as a high-school science project that caught the attention of the Office of Naval Research, the Air Force, and ultimately Capital Factory. Today, the company has completed large-scale Phase I and II clinical trials and is preparing for Phase III on the road to full FDA approval.

For founders and investors, the conversation offers a masterclass in building a venture where science, regulation, and commercialization collide. David’s journey reveals how deep-tech startups blend government contracts, clinical milestones, and strategic capital to bring ambitious, impactful technology into the real world.

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