Unbiased Science

Immunity Mutiny: Demystifying Autoimmunity

Apr 9, 2025
Dr. Aimee Pugh-Bernard, an Associate Professor of Immunology and Microbiology, dives into the complex world of autoimmunity. She discusses how autoimmune disorders develop, particularly focusing on systemic lupus erythematosus, and the challenges faced in diagnosing these conditions. The conversation highlights the critical roles of genetics and environmental triggers, while also debunking common myths, especially around vaccinations. Listeners gain insights into evidence-based management strategies and the alarming rise of autoimmune diseases.
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INSIGHT

Autoimmunity as Friendly Fire

  • Autoimmunity happens when the immune system mistakenly attacks the body, like friendly fire in the military.
  • Different autoimmune diseases target different tissues, but all involve misidentification of self as foreign.
INSIGHT

Types of Autoimmune Diseases

  • Autoimmune diseases include organ-specific and systemic types, distinguished by their targets.
  • For example, type 1 diabetes targets pancreatic cells, while lupus affects multiple organs.
INSIGHT

Autoantibodies Alone Don't Confirm Disease

  • Diagnosis of autoimmune diseases starts with detecting autoantibodies via blood tests.
  • However, autoantibodies alone without symptoms do not confirm disease presence.
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