Use of Direct Oral Anticoagulants vs. VKA for VTE Treatment

Direct oral anticoagulants have become the standard of care for treating VTE due to their lower risk of major bleeding, fatal bleeding, and intracranial bleeding compared to VKA. They are more convenient as they do not require routine monitoring and have fixed doses. Considerations for using VKA include drug interactions, poor renal function, and cost differences. Among DO-ACs like Big A Tran, River OxiBan, Apixaban, and Doxaban, there are no head-to-head trials determining superiority, but generally River OxiBan and Apixaban are commonly used due to ease of administration and lower bleeding risks.