Challenges in Diagnosing Vasculitis

Confirming a diagnosis of ANCA-associated vasculitis often presents challenges, particularly when biopsies are difficult or declined by patients. While biopsies can provide definitive evidence, certain procedures, like nerve or lung biopsies, may be more complex and require collaboration with specialists. Additionally, there is a concern about interpreting serologies, as positive tests can arise from conditions other than vasculitis, such as infections or other autoimmune disorders. The importance of accurate pathology is underscored, as a misinterpretation of biopsy results can lead to incorrect diagnoses and treatment plans.