The Bio Report cover image

The Bio Report

Going to Extremes to Discover New Drugs

Oct 16, 2024
Ashley Zehnder, the founder and CEO of Fauna Bio, dives into the fascinating world of hibernation and its secrets for human health. She discusses how the genomic data from hibernating animals can unlock potential treatments for obesity, heart attacks, and more. With her company's use of AI, they're identifying gene-disease links that could lead to groundbreaking drug therapies. The partnership with Eli Lilly highlights the innovative strategies being used in drug discovery, particularly in tackling obesity and enhancing our understanding of tissue regeneration.
31:38

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Quick takeaways

  • Understanding the biology of hibernation can lead to new drug innovations for obesity, heart disease, and neuroprotection.
  • Fauna Bio's AI platform utilizes genomic data from hibernating animals to enhance drug discovery and develop innovative therapeutic targets.

Deep dives

Exploration of Hibernation's Biology

Hibernation demonstrates remarkable biological adaptations that go beyond simple dormancy, with animals able to undergo severe physiological changes without suffering tissue damage. Research into this phenomenon spans decades and reveals similar hibernation traits in a range of mammals, underscoring the evolutionary advantages conferred by these adaptations. Notably, hibernating animals show profound abilities to repair heart damage and maintain muscle integrity during extended periods without food or water. FaunaBio focuses on leveraging genomic data from these animals to uncover insights that could inform treatments for human health conditions such as obesity, heart disease, and neurodegenerative disorders.

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