Join us on this podcast as we discuss Renal Replacement Therapy with Professor Sean Bagshaw from the University of Alberta Hospital, Edmonton, Canada. Dr. Bagshaw is Professor and Chair for the Department of Critical Care Medicine at the University of Alberta in Edmonton, Canada. He completed medical school and residency training at the University of Calgary (Doctor of Medicine – 2000; Internal Medicine – 2003; Critical Care Medicine – 2005; Master of Science in Epidemiology – 2005) prior to completing a Critical Care Nephrology fellowship in the Department of Intensive Care Medicine, at the Austin Hospital in Melbourne, Australia. Dr. Bagshaw works as a full-time staff intensivist in two of the busiest and highest acuity intensive care units in Alberta – the General Systems ICU at the University of Alberta Hospital and the Cardiovascular Surgical ICU at the Mazankowski Alberta Health Institute. Dr. Bagshaw has expertise in acute kidney injury, renal replacement therapy, frailty and vulnerable patients and end-of-life care in ICU settings. He has published over 400 peer-reviewed articles and it was our absolute privilege to have him on the show. In this episode we talk about timing of replacement therapy, data around continuous and intermittent therapy, intensity of dialysis, fluid management, anticoagulation and weaning of renal replacement therapy. Articles of Interest: 1. Timing of Initiation of  Renal-Replacement Therapy in Acute Kidney Injury. New England Journal of  Medicine. 2020 Jul 16;383(3):240–51. 2. Zarbock A, Kellum JA, Schmidt C, van  Aken H, Wempe C, Pavenstädt H, et al. Effect of Early vs Delayed Initiation of  Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute  Kidney Injury. JAMA. 2016 May 24;315(20):2190. 3. Barbar SD, Clere-Jehl R, Bourredjem A,  Hernu R, Montini F, Bruyère R, et al. Timing of Renal-Replacement Therapy in  Patients with Acute Kidney Injury and Sepsis. New England Journal of Medicine.  2018 Oct 11;379(15):1431–42. 4. Gaudry S, Hajage D, Schortgen F,  Martin-Lefevre L, Pons B, Boulet E, et al. Initiation Strategies for  Renal-Replacement Therapy in the Intensive Care Unit. New England Journal of  Medicine. 2016 Jul 14;375(2):122–33. 5. Jaber S, Paugam C, Futier E, Lefrant  JY, Lasocki S, Lescot T, et al. Sodium bicarbonate therapy for patients with  severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a  multicentre, open-label, randomised controlled, phase 3 trial. The Lancet.  2018 Jul;392(10141):31–40. 6. Intensity of Continuous  Renal-Replacement Therapy in Critically Ill Patients. New England Journal of  Medicine. 2009 Oct 22;361(17):1627–38. 7. Intensity of Renal Support in  Critically Ill Patients with Acute Kidney Injury. New England Journal of  Medicine. 2008 Jul 3;359(1):7–20.