Outside the box thinking for drug discovery success
Nov 30, 2023
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Explore the latest research on synthetic microbiomes, drug repurposing, and muco-adhesive drug delivery. Learn about the potential of microbiome therapies, the benefits and challenges of drug repurposing, advancements in clinical data availability, and the potential of muco-adhesive drug delivery systems. Discover how these innovative approaches are shaping the future of drug discovery.
Building a synthetic microbiome allows scientists to study the links between the microbiome and human health, potentially leading to the development of first-in-class microbiome therapies.
Drug repurposing offers benefits such as faster time to market, but challenges remain in establishing safety, dosage, and formulation for repurposed drugs.
Deep dives
Stanford researchers construct the most complete synthetic microbiome
Stanford University researchers have successfully built a synthetic microbiome consisting of over 100 bacterial species that were transplanted into mice. This synthetic microbiome allows scientists to study the links between the microbiome and human health in a more systematic way, potentially leading to the development of first-in-class microbiome therapies.
Highs and lows of drug repurposing
Drug repurposing, the process of finding new clinical targets for approved and unapproved drugs, offers several benefits such as faster time to market and potential cost savings. However, challenges remain in establishing safety, exposure, optimal dosage, and formulation for repurposed drugs. Technological advancements, such as artificial intelligence and machine learning, can facilitate the identification of new uses for existing drugs and the rescue of failed therapies.
Unlocking the potential of muco-adhesive drug delivery
Muco-adhesive drug delivery is an innovative approach that maximizes the chances of successfully bringing a new API to market and enhances the efficacy of approved drugs. By interacting with the mucous layer, muco-adhesive formulations can be applied to various tissue sites in the body. Medicinal chemists, formulators, and drug developers must consider drug delivery systems early in the development process, utilize appropriate testing systems that mimic real-world conditions, and contemplate regulatory requirements from the start to unlock the full potential of muco-adhesive drug delivery.
In the first article, Rebecca McClellan, Scientific Program Manager, Research, Development & Communications, explains how scientists are learning more about the connections between the microbiome and human health to potentially develop first-in-class microbiome therapies.
In the second article, DDW Editor Reece Armstrong explores the rise of drug repurposing and the benefits and disadvantages it brings to drug discovery and development.
In the third article, Ashley Rein, Global Market Manager for Topical Drug Delivery at Lubrizol Life Science Health (LLS Health), explains how by using mucoadhesive drug delivery, developers can bring novel drugs to market and maximise the efficacy of pre-existing APIs.
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