Optimal Protein Podcast with Vanessa Spina The New Protein Guidelines, Weight Loss Drugs & Fat Regain + Carb Tolerance & Fat Loss — Dr. Gabrielle Lyon Recap
Skip to the start of the episode: 11:52
In today's Friday solo recap on the Optimal Protein Podcast, I break down the most important takeaways from my recent conversation with Dr. Gabrielle Lyon — and why this episode has major implications for fat loss, metabolic health, and women's body composition.
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One of the biggest themes of our discussion was that muscle is not just about aesthetics. It's a metabolic organ, and preserving it is foundational for long-term health — especially for women as we age.
I also connect this conversation to the new protein recommendations reflected in the 2025–2030 Dietary Guidelines, which now align far more closely with modern protein science. For the first time, official guidance is moving beyond minimums designed to prevent deficiency and toward intakes that actually support muscle preservation, metabolic health, and satiety. We also cover a brand new study on weight loss drugs and fat regain.
In this recap, I cover:
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Why we don't have an "overfat" problem — we have an undermuscled problem
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Why midlife fat gain is not inevitable (and not just about hormones)
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How carb tolerance and activity level influence fat storage
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Why excess carbohydrates quietly work against fat loss when muscle demand is low
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The overlooked role of muscle blood flow and intramuscular fat
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Why under-eating accelerates muscle loss in women
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How weight loss drugs can worsen fat regain if muscle isn't protected
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Why strength training is non-negotiable — but must be appropriate
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Why protein isn't just calories, but a signal for muscle and metabolism
If your goals include fat loss, body recomposition, and aging strong, this episode will help you rethink how protein, carbs, and muscle fit together — and why preserving muscle is the real long-term strategy.
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🎙 The content in this podcast is for informational purposes only and not nutritional or medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.