This Week in Virology TWiV 1282: Clinical update with Dr. Daniel Griffin
Dec 27, 2025
Dr. Daniel Griffin, an infectious disease clinician and researcher, dives into pressing viral concerns, from a new high path influenza case in Wisconsin to the Marburg outbreak in Ethiopia. He highlights the alarming rise of measles cases across North America and discusses the effectiveness of current influenza antivirals. Key insights include the higher mortality rates linked to COVID-19 compared to influenza, and the promising data on nirsevimab for RSV prevention in infants. The importance of vaccination remains a recurring theme throughout their insightful chat.
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New H5N1 Spillover Into Dairy Cattle
- USDA confirmed a new H5N1 spillover into a Wisconsin dairy herd, genetically distinct from prior cattle events.
- This indicates ongoing wildlife-to-cattle transmission and the need for surveillance at the livestock–wildlife interface.
Marburg Cases Detected In Ethiopia
- Ethiopia reported laboratory-confirmed Marburg cases with high case fatality early in the outbreak.
- Rapid detection highlights persistent risk from high-consequence zoonotic viruses in resource-limited settings.
Measles Resurgence Threatens Elimination
- Over 2,000 measles cases were reported in the U.S., threatening the status of elimination.
- Low vaccination coverage is causing hospitalizations and deaths that are entirely preventable.
