Unbiased Science

T-errific T-Regs: Nobel Prize Winning Immune Cells

Oct 15, 2025
Guest
Dr. Yasmin Mohseni
Dr. Yasmin Mohseni, an acclaimed immunologist and expert in regulatory T cell research, joins the discussion to unpack the recent Nobel Prize-winning discoveries. She delves into the vital role of T-Regs in preventing autoimmunity and advancing organ transplantation. The conversation tackles how tumors exploit T-Regs, exploring the delicate balance between treating cancer and avoiding autoimmune reactions. Dr. Mohseni also shares thrilling advancements in immunotherapy and the potential for curing once-incurable diseases, igniting hope for the future.
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ANECDOTE

Nobel Recognition Felt Personal

  • Dr. Yasmin Mohseni recalls waking to many messages after the Nobel Prize announcement about Tregs.
  • She felt validated and excited because pioneers like Sakaguchi, Ramsdell, and others finally received broad recognition.
INSIGHT

Tregs Maintain Immune Balance

  • Regulatory T cells (Tregs) actively switch off inflammation to restore immune balance after an infection.
  • Without Tregs the body risks unchecked inflammation and widespread autoimmunity.
INSIGHT

Foundations Of Treg Biology

  • Sakaguchi discovered a unique Treg population that enforces self-tolerance and prevents autoimmunity.
  • Later work identified FOXP3 as a master regulator gene that defines Treg identity and function.
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