Mast Cell Matters: Deep dives on MCAS with Tania Dempsey, MD - Presented by The POTScast Introduction to mast cells and mast cell activation syndrome (MCAS) with Dr. Tania Dempsey
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Nov 8, 2023 Delve into the fascinating world of mast cells and their role in the immune system. Learn how surgical materials can trigger mast cell activation syndrome and amplify reactions to the environment. The conversation highlights the symptoms of MCAS, particularly in women during hormonal shifts. Discover the link between dysfunctional mast cells and conditions like POTS, emphasizing the need for patient education. Explore the journey of understanding this often-misunderstood syndrome and the importance of advocacy in advancing treatment options.
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Discovery of MCAS Expertise
- Dr. Tania Dempsey discovered MCAS through a challenging patient case in 2014 and reached out to expert Dr. Lawrence Afrin.
- This interaction opened her eyes to mast cell disorders, shaping her expertise and clinical focus.
Mast Cells' Defensive Role
- Mast cells are specialized white blood cells residing in tissues exposed to the environment as first responders.
- They guard respiratory, gastrointestinal, skin, nervous and vascular tissues against harmful foreign agents.
Dual Nature of Mast Cells
- Mast cells protect against infections by releasing inflammatory chemicals when triggered, which also recruit other immune cells.
- Their inflammatory mediators help fight pathogens but can cause tissue inflammation and disease if overactive.