OHSU sleep researchers get $4 million grant to see if bright light therapy improves outcomes for people with traumatic brain injuries

For years now, scientists have shown that daily exposure to bright light therapy, which simulates the intensity of outdoor light, can be beneficial for people with insomnia and other sleep disorders, Seasonal Affective Disorder or other forms of depression. But what if bright light therapy can help people recover from concussions or other traumatic brain injuries? And what if it can also lower the risk of neurodegenerative diseases like Parkinson’s or Alzheimer’s, which people with TBIs are at higher risk for? 

Scientists at Oregon Health & Science University were recently awarded a $4 million grant from the U.S. Department of Defense to explore these questions and possibly unlock more secrets about sleep and its effect on health. The OHSU researchers will recruit nearly 120 military veterans who have suffered a TBI. The participants will be given a light box to use at home for one hour each morning for four weeks. Blood samples will be drawn from participants to look for changes in markers that signal inflammation in the brain and changes in oxygen uptake in brain cells. 

MRI scans of participants’ brains will also help reveal if the bright light therapy has improved activity of the glymphatic system - a relatively recent discovery about the role of sleep in reducing toxins that can lead to neurodegenerative diseases like Alzheimer’s.

Joining us for more details of the study and to share new insights about sleep science is Jonathan Elliott, assistant professor of neurology and co-director of the Sleep & Health Applied Research Program at OHSU.