Changing the Relationship of Underserved Populations with Clinical Trials: Dr. Keolu Fox, Co-Founder, Native BioData Consortium & Assistant Professor, University of California, San Diego
Mar 2, 2023
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Dr. Keolu Fox, an indigenous futurist and co-founder of the Native BioData Consortium, passionately advocates for diversity in clinical trials. He shares his journey into healthcare and genomics, emphasizing the need to include underserved populations, especially indigenous communities, in research to ensure equitable advancements. He explores how embracing ancestral wisdom can lead to sustainable practices and calls for a more inclusive approach in tech and genomics, highlighting the ethical implications of healthcare innovations.
Dr. Keolu Fox emphasizes that increasing diversity in clinical trials is crucial to address healthcare inequities faced by underserved populations.
He advocates for transparency and community engagement in genomic research to build trust and create equitable healthcare solutions.
Deep dives
Dr. Keolu Fox's Journey into Genomics
Dr. Keolu Fox, an associate professor at the University of California, San Diego, is the first native Hawaiian with a PhD in genomics. His journey into the field was influenced by his upbringing in remote indigenous communities, where he observed healthcare inequities firsthand. His experiences, coupled with a significant family background in public health, have shaped his understanding of the challenges in healthcare delivery among marginalized populations. Through his work and advocacy, he emphasizes the need for diverse representation in genomic studies, moving beyond the Eurocentric focus that has traditionally dominated the field.
The Importance of Diverse Genomic Data
The podcast highlights the unsettling reality that indigenous populations are often underrepresented in clinical and genomic studies, which skews the understanding of genetic diversity and its implications for health. Dr. Fox points out that current research fails to reflect the true spectrum of human genetic variation, which is critical for developing effective treatments for diseases. This lack of representation not only perpetuates health disparities but also undermines trust between scientific communities and the very populations that research aims to serve. To combat this, there is a call for inclusive recruitment strategies and a shift towards community-centered research models that prioritize equity.
Building Trust with Indigenous Communities
Dr. Fox discusses the necessity of transparency and honest communication in building trust with historically marginalized communities when conducting genomic research. He emphasizes the importance of engaging communities as partners rather than mere subjects, ensuring that they understand the potential uses and misuses of their genetic data. By fostering open dialogue and creating opportunities for investment and benefit sharing, researchers can address historical distrust rooted in past unethical practices. This innovative approach could pave the way for a more equitable future for all participants involved in genomic studies.
Technological Innovations and Ethical Considerations
The discussion also delves into the role of technology, particularly in how advancements in genomic research can either exacerbate or mitigate health disparities. Dr. Fox warns that as algorithms are trained predominantly on data from a homogenous population, they may inadvertently perpetuate inequities in healthcare outcomes. He advocates for thoughtful investment in technologies that prioritize diverse datasets to ensure that all communities benefit from advancements in genomic medicine. Moreover, he proposes new frameworks for benefit sharing that foster sustainable relationships between researchers and indigenous populations, ultimately creating a more equitable healthcare landscape.
Indigenous futurist and technologist Dr. Keolu Fox joins us this week to discuss how increased diversity in clinical trials can transform healthcare for underserved populations and for the overall healthcare system.
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