Jon Hamilton, NPR science correspondent and expert on brain mapping, joins to discuss a groundbreaking atlas detailing over 3,000 brain cell types. This innovative map, part of the NIH's BRAIN initiative, sheds light on brain structure and function, potentially enhancing our understanding of human uniqueness and disease roles. Discover the fascinating connections between technology, ethics, and research, along with the quirky reference to 'splatter neurons,' making complex science relatable and engaging!
The newly published brain atlas provides a detailed map of over 3,000 types of brain cells, enabling scientists to study disease mechanisms and identify vulnerable cell types.
The brain atlas reveals a vast range of specialized cell types in the human brain and highlights similarities and differences between human and animal brains, aiding in understanding the human brain's capacity and studying brain diseases.
Deep dives
The Brain Mapping Atlas: Navigating the Complexity of the Human Brain
Scientists have developed a new atlas that maps different types of cells in the human brain. This atlas, created as part of the Brain Initiative launched by President Obama in 2013, involved hundreds of scientists and took years to complete. With over 170 billion cells and more than 3,000 identified cell types, mapping the human brain is an important step in understanding human uniqueness, individual differences, brain development, and disease vulnerabilities. This atlas provides a foundational reference for studying disease mechanisms and identifying vulnerable cell types. By using new technologies and embracing collaborative efforts, scientists were able to gather data from human and animal brains, including mice, chimps, and gorillas, shedding light on cell types, gene expression, and the connections between neurons. This atlas will accelerate research on brain diseases like Alzheimer's, schizophrenia, and depression, potentially leading to new therapeutic approaches.
Unveiling the Diversity of Brain Cell Types
The brain atlas reveals a vast range of cell types in the human brain, including neurons and glial cells. Neurons, responsible for electrical signal transmission, make up about 86 billion cells, while glial cells, playing a supportive role and sending chemical signals, account for about 85 billion cells. Within these broad categories, researchers have identified numerous subcategories of cells, each with specialized functions. For example, there are photo receptor neurons that respond to light and astrocytes, a type of glial cell, that maintain the blood-brain barrier and provide nutrients to neurons. These cell types form a parts list for the brain, but there is still much to discover about their specific roles and functions.
Insights for Understanding Human Brain Capacity and Development
The brain atlas highlights similarities and differences between human and animal brains. By comparing human brain cells to those of mice, chimps, and gorillas, scientists can better grasp what makes humans distinct. For instance, humans possess specialized neurons for visual processing that are absent in mice, as humans prioritize visual information while mice rely more on their sense of smell. Understanding these differences is crucial for accurately using animal models to study human diseases. Furthermore, exploring gene expression patterns has revealed that the same cell types exist in humans and apes, but the genes turned on or off differ, underscoring the significance of wiring rather than the presence of distinct cell types in language processes. The brain atlas will undoubtedly deepen our understanding of the human brain's capacity and aid in studying brain diseases.
The human brain has more than 170 billion cells. A newly published atlas offers the most detailed maps yet of the location, structure and, in some cases, function of more than 3,000 types of brain cells. The atlas could help scientists understand what makes humans unique in the animal kingdom and the roles different brain cells play in disease. Science correspondent Jon Hamilton talks to host Regina G. Barber about the findings from this new map, a product of the NIH's BRAIN initiative. Plus, what the heck splatter neurons have to do with all of this!