VJHemOnc Podcast Highlights from iwCAR-T 2025: improving the efficacy and safety of CAR T-cells & access in the community
May 19, 2025
Experts share cutting-edge strategies to enhance CAR T-cell therapy effectiveness while minimizing side effects. Insightful discussions reveal how diet can impact treatment outcomes, highlighting surprising metabolites. Keynote talks explore accelerating CAR T-cell therapeutics using CRISPR technology. The challenges of improving access to these therapies in community settings are tackled, underscoring the importance of collaboration between healthcare providers to ensure patients receive optimal care.
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Protein Enhances CAR T Persistence
- Enhancing CAR T-cell activity and persistence is key to preventing relapses in multiple myeloma and lymphoma.
- A protein called CAR enhancer selectively boosts CAR T-cell function and could improve patient responses.
Inflammation Impairs CAR T Effectiveness
- Systemic inflammation reduces CAR T-cell therapy efficacy and increases toxicity.
- Using JAK1 inhibitor itacitinib to suppress inflammation may improve long-term remission rates in lymphoma patients.
Ketogenic Diet May Boost CAR T
- A ketogenic diet boosts CAR T-cell anti-tumor effects in animal models by increasing interferon gamma.
- Clinical trials are investigating ketone supplements to enhance CAR T efficacy in patients, but no recommendations yet.