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Have you heard of the "bubble boy?" In this episode, we outline an approach to hypogammaglobulinemia - a fascinating outpatient medicine topic! Episode written by Dr. Vivian Szeto (Internal Medicine resident) and reviewed by Dr. Rongbo Zhu (Clinical Allergy and Immunology) and Dr. Marko Mrkobrada (General Internal Medicine). Infographic by Dr. Valarie Kim (Internal Medicine resident).