Jerry Ratcliffe chats with Keith Humphreys, an influential figure in drug policy and a professor at Stanford University. They discuss the dangers of synthetic opioids, the role of academics in advising government, and the differences between drug policies in San Francisco and Portugal. Humphreys emphasizes the importance of a balanced approach to drug policy, combining public health and public safety measures. He highlights the need for coercion in certain cases to encourage behavior change and protect communities. The conversation also touches on movies that depict addiction and the drug trade, such as "Trainspotting" and "Layer Cake."