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Ep97: John Evans on Base Edited Therapeutics

The Long Run with Luke Timmerman

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What's a Dman Aca?

The watson crick base pairing of a and t and c and g, is driven by chemistry that bonds in a certain way. If you deminate that group, if you literally just cleave off the amen group, you get a different base. It will par differently and will therefore carry different information. And so all that is about chemistry, which means that we don't really care what cel type, dividing or non dividing it, it'll happen to us very efficiently.

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