Reactive Oxygen Species (ROS) and Their Importance in the Cell

Dr Glenn McConell chats with Dr Carlos Henríquez-Olguín from The University of Copenhagen, Denmark. Carlos is an up and coming rising star exercise metabolism researcher. He discusses the challenges of doing mechanistic exercise research in Chile and how he ended up moving to the University of Copenhagen. Language challenges etc. He has been doing really ground breaking research on reactive oxygen species (ROS) and contraction/exercise and already won awards for his research. Twitter: @MuscleBiology.
0:00. Introduction/reason invited Carlos onto Inside exercise
4:00. Challenges doing mechanistic exercise research in Chile etc
9:37. Cell culture and mouse ROS experiments in Chile
12:11. How got into reactive oxygen species research
14:25. Muscle dystrophy, contraction and ROS
16:09. Chronic versus acute increases in ROS
16:49. How/why moved to the University of Copenhagen
19:20. No success with initial research at the University of Copenhagen
20:30. Made his own luck
21:39. The need for patience from supervisor if facing challenges
23:40. Language challenges when coming from Chile
26:30. Giving better visibility to early career researchers
31:04. Prizes he has won in both exercise and ROS
34:08. Challenges publishing when from less scientifically recognized countries
36:22. What are reactive oxygen species?
37:50. Theory of ROS and aging
38:30. ROS, antioxidants, oxidative stress, ROS signaling
40:05. Muscle antioxidants, exercise and disease
42:19. Where in muscle are ROS coming from during contraction?
45:02. NOX2, RAC1, glucose uptake with contraction
47:21. What’s activating ROS production during contraction?
48:11. Nitric oxide vs ROS vs both?
50:15. Acute versus chronic increases in ROS
53:16. Best exercise for increasing your antioxidant defenses?
57:50. High ROS production from mitochondria in some diseases
59:30. Can exercise improve these diseases by producing ROS?
1:00:41. Compartmentalization of ROS production in muscle
1:02:03. Should supplement with antioxidants?
1:07:23. Increased mortality in people taking high levels of supplements
1:06:32. Antioxidant supplements improve those with chronically high ROS?
1:09:20. Mitochondria ROS and mitochondria specific antioxidants
1:14:37. Exercise and antioxidant gene expression
1:16:50. Mitochondria have antioxidant enzymes
1:17:50. Carlos’s methods to study ROS with contraction/insulin resistance
1:23:20. Takeaway messages
1:27:39. ROS and glucose uptake during exercise
1:29:43. Outro (9 seconds) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
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Not medical advice